Linear Relationship between ZIA and Change in Duration of Colds
Linear Relationship between ZIA Values and Changes in the Duration of Common Colds

Positive, neutral and negative ZIA values and resultant changes in duration of common colds.

Research zinc lozenges having a positive ZIA value reduced the duration of common colds in a dose-response manner. ZIA 25 lozenges reduced duration of colds by about 1-1/2 day, while lozenges having a ZIA value of 44 reduced the duration of colds by 4.8 days, and lozenges having a ZIA value of 100 reduced the duration of colds by 7 days. Lozenges having a zero ZIA did not have any effect on colds. Zinc lozenges released negatively charged zinc species at physiologic pH (as shown in the lower-left corner of the above figure) and increased the duration and severity of common colds in a dose-response manner. Although we do not know of any commercial zinc lozenges with a negative ZIA value, it is possible that they are on the market.




homepage - Zinc Acetate Lozenges for Common Colds